E2F7 and E2F8 Keep the E2F Family in Balance
نویسندگان
چکیده
منابع مشابه
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription
The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the characterization of human and murine E2F8, a new member of the E2F family. Sequence analysis of E2F8 predicts the presence of two distinct E2F-related DNA binding domains sugge...
متن کاملDNA-damage response control of E2F7 and E2F8.
Here, we report that the two recently identified E2F subunits, E2F7 and E2F8, are induced in cells treated with DNA-damaging agents where they have an important role in dictating the outcome of the DNA-damage response. The DNA-damage-dependent induction coincides with the binding of E2F7 and E2F8 to the promoters of certain E2F-responsive genes, most notably that of the E2F1 gene, in which E2F7...
متن کاملThe atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently up-regulated during oncogene-induced senescence, a setting where it ac...
متن کاملSynergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
The E2f7 and E2f8 family members are thought to function as transcriptional repressors important for the control of cell proliferation. Here, we have analyzed the consequences of inactivating E2f7 and E2f8 in mice and show that their individual loss had no significant effect on development. Their combined ablation, however, resulted in massive apoptosis and dilation of blood vessels, culminatin...
متن کاملCloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation.
The E2F transcription factor family plays a crucial and well established role in cell cycle progression. Deregulation of E2F activities in vivo leads to developmental defects and cancer. Based on current evidence in the field, mammalian E2Fs can be functionally categorized into either transcriptional activators (E2F1, E2F2, and E2F3a) or repressors (E2F3b, E2F4, E2F5, E2F6, and E2F7). We have i...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2008
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2007.12.017